The habenula receives input from the brain via the stria medullaris thalami and outputs to many midbrain areas involved in releasing neurotransmitters, such as dopamine, norepinephrine, and serotonin.
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Deep brain stimulation of the major afferent bundle ( i . e ., stria medullaris thalami ) of the lateral habenula has been used for treatment of depression where it is severe, protracted and therapy-resistant.
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